| Date | Location | Result | |
| May 07, 2000 | Quincy, IL | #30 QUINCY 7, SOUTHERN INDIANA 6 | Box score |
| May 05, 2000 | Quincy, IL | SOUTHERN INDIANA 6, #30 QUINCY 3 | Box score |
| May 05, 2000 | Quincy, IL | #30 QUINCY 8, SOUTHERN INDIANA 4 | Box score |
| Apr 30, 2000 | Indianapolis, IN | INDIANAPOLIS 7, SOUTHERN INDIANA 3 | Box score |
| Apr 30, 2000 | Indianapolis, IN | INDIANAPOLIS 4, SOUTHERN INDIANA 3 | Box score |
| Apr 29, 2000 | Highland Heights, KY | NORTHERN KENTUCKY 13, SOUTHERN INDIANA 6 | Box score |
| Apr 29, 2000 | Highland Heights, KY | NORTHERN KENTUCKY 7, SOUTHERN INDIANA 3 | Box score |
| Apr 25, 2000 | Murray, KY | MURRAY STATE 4, SOUTHERN INDIANA 3 | Box score |
| Apr 18, 2000 | Lebanon, IL | MCKENDREE 5, SOUTHERN INDIANA 1 | Box score |
| Apr 22, 2000 | Evansville, IN | SOUTHERN INDIANA 10, KENTUCKY WESLEYAN 4 | Box score |
| Apr 21, 2000 | Evansville, IN | SOUTHERN INDIANA 4, KENTUCKY WESLEYAN 3 | Box score |
| Apr 21, 2000 | Evansville, IN | SOUTHERN INDIANA 7, KENTUCKY WESLEYAN 6 | Box score |
| Apr 19, 2000 | Edwardsville, IN | SIU EDWARDSVILLE 12, SOUTHERN INDIANA 10 | Box score |
| Apr 16, 2000 | Romeoville, IL | SOUTHERN INDIANA 10, LEWIS 7 | Box score |
| Apr 16, 2000 | Romeoville, IL | SOUTHERN INDIANA 3, LEWIS 1 | Box score |
| Apr 15, 2000 | Kenosha, WI | WISCONSIN-PARKSIDE 7, SOUTHERN INDIANA 6 | Box score |
| Apr 15, 2000 | Kenosha, WI | SOUTHERN INDIANA 2, WISCONSIN-PARKSIDE 0 | Box score |
| Apr 13, 2000 | Evansville, IN | OAKLAND CITY 9, SOUTHERN INDIANA 6 | Box score |
| Apr 12, 2000 | Owensboro, KY | SOUTHERN INDIANA 1, BRESCIA 0 | Box score |
| Apr 09, 2000 | Evansville, IN | #18 MO.-ST. LOUIS 5, SOUTHERN INDIANA 3 | Box score |
| Apr 09, 2000 | Evansville, IN | #18 MO.-ST. LOUIS 6, SOUTHERN INDIANA 2 | Box score |
| Apr 08, 2000 | Evansville, IN | #18 MO.-ST. LOUIS 13, SOUTHERN INDIANA 6 | Box score |
| Apr 05, 2000 | Evansville, IN | SIU EDWARDSVILLE 3, SOUTHERN INDIANA 2 | Box score |
| Apr 05, 2000 | Evansville, IN | SOUTHERN INDIANA 2, SIU EDWARDSVILLE 1 | Box score |
| Apr 01, 2000 | Louisville, KY | BELLARMINE 8, SOUTHERN INDIANA 2 | Box score |
| Apr 01, 2000 | Louisville, KY | SOUTHERN INDIANA 2, BELLARMINE 1 | Box score |
| Mar 30, 2000 | Oakland City, IN | OAKLAND CITY 1, SOUTHERN INDIANA 0 | Box score |
| Mar 30, 2000 | Oakland City, IN | SOUTHERN INDIANA 5, OAKLAND CITY 4 | Box score |
| Mar 26, 2000 | Evansville, IN | SAINT JOSEPH'S 9, SOUTHERN INDIANA 5 | Box score |
| Mar 26, 2000 | Evansville, IN | SOUTHERN INDIANA 5, SAINT JOSEPH'S 2 | Box score |
| Mar 25, 2000 | Evansville, IN | SOUTHERN INDIANA 7, IPFW 2 | Box score |
| Mar 25, 2000 | Evansville, IN | SOUTHERN INDIANA 12, IPFW 3 | Box score |
| Mar 22, 2000 | Evansville, IN | SOUTHERN INDIANA 6, BRESCIA 5 | Box score |
| Mar 21, 2000 | Indianapolis | SOUTHERN INDIANA 2, IUPUI 1 | Box score |
| Mar 21, 2000 | Indianapolis | IUPUI 2, SOUTHERN INDIANA 0 | Box score |
| Mar 18, 2000 | Memphis, TN | SOUTHERN INDIANA 4, CHRISTIAN BROTHERS 0 | Box score |
| Mar 18, 2000 | Memphis, TN | SOUTHERN INDIANA 7, CHRISTIAN BROTHERS 6 | Box score |
| Mar 14, 2000 | Evansville, IN | SOUTHERN INDIANA 12, OAKLAND CITY 1 | Box score |
| Mar 12, 2000 | Milledgeville, GA | #6 GEORGIA COLLEGE 5, SOUTHERN INDIANA 1 | Box score |
| Mar 11, 2000 | South Carolina | PRESBYTERIAN 8, SOUTHERN INDIANA 7 | Box score |
| Mar 10, 2000 | Anderson, SC | SOUTHERN INDIANA 18, ANDERSON 9 | Box score |
| Mar 09, 2000 | Augusta, GA | SOUTHERN INDIANA 13, AUGUSTA STATE 7 | Box score |
| Mar 07, 2000 | Augusta, GA | AUGUSTA STATE 6, SOUTHERN INDIANA 3 | Box score |
| Mar 06, 2000 | Kennesaw, GA | #20 KENNESAW STATE 4, SOUTHERN INDIANA 3 | Box score |
| Mar 05, 2000 | Carrollton, GA | SOUTHERN INDIANA 11, WEST GEORGIA 1 | Box score |
| Mar 05, 2000 | Carrollton, GA | WEST GEORGIA 4, SOUTHERN INDIANA 3 | Box score |
| Mar 04, 2000 | Carrollton, GA | WEST GEORGIA 5, SOUTHERN INDIANA 4 | Box score |
| Feb 29, 2000 | Skyhawk Field | TENNESSEE-MARTIN 20, SOUTHERN INDIANA 19 | Box score |
| Feb 27, 2000 | Evansville, IN | SOUTHERN INDIANA 10, TRUMAN STATE 8 | Box score |
| Feb 27, 2000 | Evansville, IN | SOUTHERN INDIANA 11, TRUMAN STATE 7 | Box score |
| Feb 25, 2000 | Evansville, IN | MCKENDREE 10, SOUTHERN INDIANA 6 | Box score |
| Feb 20, 2000 | Montevallo, AL | MONTEVALLO 9, SOUTHERN INDIANA 2 | Box score |
| Feb 20, 2000 | Montevallo, AL | MONTEVALLO 8, SOUTHERN INDIANA 2 | Box score |
| Feb 19, 2000 | Huntsville, AL | #2 UA-HUNTSVILLE 2, SOUTHERN INDIANA 1 | Box score |
| Feb 19, 2000 | JOE DAVIS STADIUM | #2 UA-HUNTSVILLE 6, SOUTHERN INDIANA 3 | Box score |