| Date | Location | Result | |
| 02/13/21 | Evansville, IN (Screaming Eagles Arena) | Drury 93, Southern Indiana 64 | Box score |
| 02/06/21 | Kansas City, MO (Mason-Haplin FH) | Southern Indiana 96, Rockhurst 86 (OT) | Box score |
| 02/04/21 | Liberty, MO (Mabee Center) | William Jewell 70, Southern Indiana 58 | Box score |
| 02/02/21 | Quincy, IL (Pepsi Arena) | Quincy 69, Southern Indiana 61 | Box score |
| 01/30/21 | Evansville, IN (Screaming Eagles Arena) | Truman State 73, Southern Indiana 67 | Box score |
| 01/28/21 | Evansville, IN (Screaming Eagles Arena) | Southern Indiana 62, Quincy 50 | Box score |
| 01/26/21 | Evansville, IN (Screaming Eagles Arena) | Southern Indiana 56, Indianapolis 51 | Box score |
| 01/23/21 | Springfield, IL (TRAC) | Southern Indiana 77, Illinois Springfield 71 | Box score |
| 01/21/21 | Romeoville, IL (Neil Carey Arena) | Southern Indiana 64, Lewis 59 | Box score |
| 01/03/21 | Kirksville, MO (Pershing Arena) | Southern Indiana 83, Truman State 78 | Box score |
| 12/20/20 | Indianapolis, IN (Nicoson Hall) | Indianapolis 62, Southern Indiana 55 | Box score |
| 12/12/20 | Evansville, IN (Screaming Eagles Arena) | Southern Indiana 73, McKendree 48 | Box score |
| 12/05/20 | Evansville, IN (Screaming Eagles Arena) | Southern Indiana 63, Lewis 52 | Box score |
| 12/03/20 | Evansville, IN (Screaming Eagles Arena) | Southern Indiana 63, Illinois Springfield 49 | Box score |
| 11/29/20 | Evansville, IN (Screaming Eagles Arena) | Southern Indiana 80, William Jewell 55 | Box score |
| 11/27/20 | Evansville, IN (Screaming Eagles Arena) | Southern Indiana 70, Rockhurst 55 | Box score |