| Date | Location | Result | |
| 03/11/22 | Ashland, OH | Walsh 75, Southern Indiana 63 | Box score |
| 03/05/22 | Edwardsville, IL | Lewis 88, Southern Indiana 72 | Box score |
| 03/03/22 | Edwardsville, IL | Southern Indiana 92, Southwest Baptist 59 | Box score |
| 02/26/22 | Evansville, IN | Southern Indiana 68, Lindenwood (MO) 42 | Box score |
| 02/24/22 | St. Louis, MO | Southern Indiana 68, Missouri-St. Louis 58 | Box score |
| 02/19/22 | Evansville, IN | Southern Indiana 63, Missouri S&T 50 | Box score |
| 02/17/22 | Evansville, IN | Southern Indiana 70, Maryville (MO) 55 | Box score |
| 02/12/22 | Bolivar, MO | Southern Indiana 70, Southwest Baptist 48 | Box score |
| 02/10/22 | Springfield, MO | Drury 77, Southern Indiana 58 | Box score |
| 02/05/22 | Evansville, IN | Southern Indiana 86, William Jewell 51 | Box score |
| 02/04/22 | Evansville, IN | Southern Indiana 80, Rockhurst 71 | Box score |
| 01/31/22 | Saint Charles, MO | Southern Indiana 82, Lindenwood (MO) 69 | Box score |
| 01/29/22 | Quincy, IL | Southern Indiana 87, Quincy 59 | Box score |
| 01/27/22 | Kirksville, MO | Southern Indiana 78, Truman 66 | Box score |
| 01/22/22 | Evansville, IN | Lewis 72, Southern Indiana 63 | Box score |
| 01/20/22 | Evansville, IN | Southern Indiana 88, Illinois Springfield 80 | Box score |
| 01/17/22 | Evansville, IN | Southern Indiana 90, McKendree 59 | Box score |
| 01/15/22 | Indianapolis, IN | Southern Indiana 89, Indianapolis 78 | Box score |
| 01/08/22 | Evansville, IN | Southern Indiana 79, Southwest Baptist 74 | Box score |
| 12/19/21 | Tampa 79, Southern Indiana 71 | Box score | |
| 12/18/21 | Southern Indiana 90, West Texas A&M 78 | Box score | |
| 12/10/21 | Evansville, IN | Southern Indiana 108, Ky. Christian 42 | Box score |
| 12/02/21 | Springfield, IL | Southern Indiana 98, Illinois Springfield 85 | Box score |
| 11/29/21 | Evansville, IN | Southern Indiana 79, Indianapolis 62 | Box score |
| 11/24/21 | Evansville, IN | Southern Indiana 63, Ashland 58 | Box score |
| 11/20/21 | Saginaw, MI | Southern Indiana 65, Saginaw Valley 64 | Box score |
| 11/16/21 | Evansville, IN | Southern Indiana 86, Davenport 59 | Box score |
| 11/13/21 | Cedarville, OH | Cedarville 88, Southern Indiana 82 (OT) | Box score |
| 11/12/21 | Cedarville, OH | Southern Indiana 64, Ohio Dominican 58 | Box score |