| Date | Location | Result | |
| Oct 31, 2010 | Evansville, IN | Bellarmine 1, Southern Indiana 0 | Box score |
| Oct 24, 2010 | Evansville, IN | Southern Indiana 2, Kentucky Wesleyan 0 | Box score |
| Oct 22, 2010 | Evansville, IN | Bellarmine 1, Southern Indiana 1 | Box score |
| Oct 20, 2010 | Lebanon, Ill. | McKendree University 2, Southern Indiana 0 | Box score |
| Oct 17, 2010 | Evansville, IN | Southern Indiana 5, Missouri-St. Louis 0 | Box score |
| Oct 14, 2010 | Evansville, IN | Urbana 1, Southern Indiana 0 | Box score |
| Oct 10, 2010 | Rolla, MO | Southern Indiana 4, Missouri S&T 2 | Box score |
| Oct 08, 2010 | St. Louis, MO | Southern Indiana 1, Maryville University 0 | Box score |
| Oct 03, 2010 | Evansville, IN | Southern Indiana 2, Rockhurst 1 | Box score |
| Oct 01, 2010 | Evansville, IN | Southern Indiana 1, Drury 0 | Box score |
| Sep 26, 2010 | Springfield, Ill. | Southern Indiana 3, UIS 2 | Box score |
| Sep 24, 2010 | Quincy, Illinois | Quincy 2, Southern Indiana 1 | Box score |
| Sep 19, 2010 | Evansville, IN | Wisconsin-Parkside 2, Southern Indiana 0 | Box score |
| Sep 17, 2010 | Evansville,IN | Southern Indiana 1, Lewis 0 | Box score |
| Sep 12, 2010 | Indianapolis, IN | Southern Indiana 2, Indianapolis 0 | Box score |
| Sep 10, 2010 | Rensselaer,IN | Southern Indiana 3, Saint Joseph's 0 | Box score |
| Sep 08, 2010 | Oakland City, IN | Southern Indiana 7, Oakland City 0 | Box score |
| Sep 05, 2010 | Highland Heights, KY | Northern Kentucky 3, Southern Indiana 0 | Box score |
| Sep 02, 2010 | Evansville, IN | Southern Indiana 2, Bethel 0 | Box score |