| Date | Location | Result | |
| 3/12/11 | KNIGHTS HALL, LOUISVILLE, KY | Drury 65, Southern Indiana 64 | Box score |
| 3/6/11 | St. Louis, MO (Moloney Arena) | Bellarmine 87, Southern Indiana 81 | Box score |
| 3/5/11 | St. Louis, MO (Moloney Arena) | Southern Indiana 88, Drury 74 | Box score |
| 2/26/11 | Evansville, IN (PAC) | Southern Indiana 92, Wisconsin-Parkside 64 | Box score |
| 2/19/11 | Evansville, IN (PAC) | Southern Indiana 63, Northern Kentucky 60 | Box score |
| 2/17/11 | KNIGHTS HALL, LOUISVILLE, KY | Bellarmine 84, Southern Indiana 79 | Box score |
| 2/14/11 | Owensboro, KY | Kentucky Wesleyan 84, Southern Indiana 77 | Box score |
| 2/10/11 | Indianapolis, Ind. (Nicoson Hall) | Southern Indiana 90, Indianapolis 70 | Box score |
| 2/6/11 | St. Louis, MO (Chuck Smith Court) | Southern Indiana 79, Missouri-St. Louis 50 | Box score |
| 2/4/11 | Kansas City, MO (Mason-Halpin) | Southern Indiana 81, Rockhurst 61 | Box score |
| 1/29/11 | Evansville, IN (PAC) | Southern Indiana 93, Wisconsin-Parkside 81 | Box score |
| 1/27/11 | Evansville, IN (PAC) | Southern Indiana 75, Lewis 71 | Box score |
| 1/22/11 | Evansville, IN (PAC) | Indianapolis 70, Southern Indiana 68 | Box score |
| 1/17/11 | Evansville, IN (PAC | Southern Indiana 93, Kentucky Wesleyan 64 | Box score |
| 1/15/11 | Quincy, Ill. (Pepsi Arena) | Southern Indiana 80, Quincy 68 | Box score |
| 1/13/11 | Evansville, IN (PAC | Southern Indiana 75, Drury 65 | Box score |
| 1/8/11 | Evansville, IN (PAC) | Southern Indiana 76, Missouri S&T 56 | Box score |
| 1/6/11 | Evansville, IN (PAC) | Southern Indiana 76, Maryville 50 | Box score |
| 1/4/11 | Springfield, Ill. (TRAC) | Southern Indiana 78, Illinois Springfield 61 | Box score |
| 1/2/11 | Rensselaer, IN (Scharf Fieldhouse) | Southern Indiana 58, Saint Joseph's 53 | Box score |
| 12/30/10 | Evansville, IN (PAC) | Southern Indiana 65, St. Catharine 64 | Box score |
| 12/29/10 | Evansville, IN (PAC) | Southern Indiana 105, Harris-Stowe State 76 | Box score |
| 12/11/10 | KNIGHTS HALL, LOUISVILLE, KY | Southern Indiana 78, West Virginia State 67 | Box score |
| 12/10/10 | KNIGHTS HALL, LOUISVILLE, KY | Southern Indiana 105, IU-Southeast 96 | Box score |
| 12/4/10 | Evansville, IN (PAC) | Bellarmine 69, Southern Indiana 60 | Box score |
| 12/2/10 | Highland Heights, Ky. | Southern Indiana 76, Northern Kentucky 63 | Box score |
| 11/23/10 | Evansville, IN (PAC) | Southern Indiana 98, Brescia 62 | Box score |
| 11/16/10 | Evansville, IN (PAC Arena) | Southern Indiana 90, McKendree 68 | Box score |
| 11/14/10 | Evansville, IN (PAC Arena) | Southern Indiana 78, King College 70 | Box score |
| 11/12/10 | Evansville, IN (PAC Arena) | Southern Indiana 80, Ohio Dominican 63 | Box score |