| Date | Location | Result | |
| 03/04/22 | Edwardsville, IL | Mo.-St. Louis 90, Southern Indiana 68 | Box score |
| 02/28/22 | Evansville, IN | Southern Indiana 81, Ill. Springfield 52 | Box score |
| 02/26/22 | Evansville, IN | Southern Indiana 77, Lindenwood (MO) 70 (OT) | Box score |
| 02/24/22 | St. Louis, MO | Mo.-St. Louis 76, Southern Indiana 68 | Box score |
| 02/19/22 | Evansville, IN | Southern Indiana 72, Missouri S&T 65 | Box score |
| 02/17/22 | Evansville, IN | Southern Indiana 65, Maryville (MO) 58 | Box score |
| 02/12/22 | Bolivar, MO | Southwest Baptist 82, Southern Indiana 71 | Box score |
| 02/10/22 | Springfield, MO | Southern Indiana 81, Drury 63 | Box score |
| 02/05/22 | Evansville, IN | William Jewell 64, Southern Indiana 60 | Box score |
| 02/04/22 | Evansville, IN | Southern Indiana 90, Rockhurst 64 | Box score |
| 01/31/22 | Saint Charles, MO | Southern Indiana 70, Lindenwood (MO) 56 | Box score |
| 01/29/22 | Quincy, IL | Southern Indiana 80, Quincy 65 | Box score |
| 01/27/22 | Kirksville, MO | Southern Indiana 80, Truman 66 | Box score |
| 01/22/22 | Evansville, IN | Southern Indiana 67, Lewis 57 | Box score |
| 01/20/22 | Evansville, IN | Southern Indiana 66, Ill. Springfield 39 | Box score |
| 01/17/22 | Evansville, IN | McKendree 77, Southern Indiana 71 | Box score |
| 01/08/22 | Evansville, IN | Southwest Baptist 65, Southern Indiana 61 | Box score |
| 01/02/22 | Lebanon, IL | Southern Indiana 68, McKendree 55 | Box score |
| 12/20/21 | Allendale Charter Township, MI | Southern Indiana 68, Grand Valley St. 63 | Box score |
| 12/18/21 | Riepma Arena - Midland, Mich. | Southern Indiana 81, Northwood 78 (OT) | Box score |
| 12/09/21 | Evansville, IN | Southern Indiana 85, Loras 56 | Box score |
| 12/02/21 | Springfield, IL | Southern Indiana 64, Ill. Springfield 52 | Box score |
| 11/29/21 | Evansville, IN | Indianapolis 68, Southern Indiana 62 | Box score |
| 11/24/21 | Owensboro, KY | Southern Indiana 85, Ky. Wesleyan 80 (OT) | Box score |
| 11/22/21 | Cedarville, OH | Cedarville 101, Southern Indiana 88 | Box score |
| 11/18/21 | Evansville, IN | Southern Indiana 76, Oakland City 56 | Box score |