| Date | Location | Result | |
| Oct 24, 2010 | Evansville, IN | Southern Indiana 3, Kentucky Wesleyan 0 | |
| Oct 22, 2010 | Evansville, IN | Bellarmine 3, Southern Indiana 2 (OT) | |
| Oct 17, 2010 | Evansville, IN | Missouri-St. Louis 3, Southern Indiana 1 | |
| Oct 13, 2010 | Evansville, IN | Southern Indiana 3, Oakland City 2 | |
| Oct 10, 2010 | Rolla, MO | Missouri S&T 2, Southern Indiana 0 | |
| Oct 08, 2010 | St. Louis, MO | Southern Indiana 2, Maryville 1 | Box score |
| Oct 03, 2010 | Evansville, IN | Rockhurst 3, Southern Indiana 1 | Box score |
| Oct 01, 2010 | Evansville, IN | Southern Indiana 1, Drury 0 | Box score |
| Sep 26, 2010 | Springfield, Ill. | Southern Indiana 2, UIS 1 | Box score |
| Sep 24, 2010 | Quincy, Illinois | Quincy 3, Southern Indiana 2 | Box score |
| Sep 19, 2010 | Evansville, IN | Southern Indiana 2, Wisconsin-Parkside 1 | Box score |
| Sep 17, 2010 | Evansville,IN | Lewis 3, Southern Indiana 1 | Box score |
| Sep 12, 2010 | Indianapolis, IN | Indianapolis 2, Southern Indiana 0 | Box score |
| Sep 10, 2010 | Rensselaer,IN | Southern Indiana 2, Saint Joseph's 1 | Box score |
| Sep 07, 2010 | Evansville, IN | Southern Indiana 2, West Virginia Tech 0 | Box score |
| Sep 05, 2010 | Highland Heights, KY | Northern Kentucky 2, Southern Indiana 1 | Box score |
| Sep 02, 2010 | Evansville, IN | Southern Indiana 4, Saginaw Valley St. 1 | Box score |