| Date | Location | Result | |
| 10/31/21 | St. Charles, Mo. | Southern Indiana 1, Lindenwood (MO) 1 (2OT) | Box score |
| 10/29/21 | St. Louis, Mo., USA | Mo.-St. Louis 4, Southern Indiana 0 | Box score |
| 10/24/21 | Evansville, UNITED S | Missouri S&T 3, Southern Indiana 3 (2OT) | Box score |
| 10/22/21 | Evansville, UNITED S | Maryville (MO) 2, Southern Indiana 0 | Box score |
| 10/17/21 | Bolivar, UNITED STAT | Southwest Baptist 1, Southern Indiana 0 | Box score |
| 10/15/21 | Springfield, MO, UNI | Drury 3, Southern Indiana 1 | Box score |
| 10/10/21 | Evansville, UNITED S | William Jewell 2, Southern Indiana 1 (2OT) | Box score |
| 10/08/21 | Evansville, UNITED S | Southern Indiana 3, Rockhurst 1 | Box score |
| 10/03/21 | Quincy, UNITED STATE | Southern Indiana 3, Quincy 1 | Box score |
| 10/01/21 | Kirksville, UNITED S | Southern Indiana 2, Truman 0 | Box score |
| 09/26/21 | Evansville, UNITED S | Southern Indiana 2, Lewis 1 | Box score |
| 09/24/21 | Evansville, UNITED S | Illinois Springfield 2, Southern Indiana 1 | Box score |
| 09/17/21 | Indianapolis, UNITED | Indianapolis 3, Southern Indiana 0 | Box score |
| 09/12/21 | Evansville, UNITED S | McKendree 1, Southern Indiana 0 | Box score |
| 09/10/21 | Evansville, UNITED S | Southern Indiana 4, Davenport 3 (OT) | Box score |
| 09/05/21 | Evansville, UNITED S | Oakland City 2, Southern Indiana 0 | Box score |