| Date | Location | Result | |
| Nov 19, 2010 | Hillsdale, MI | Hillsdale 3, Southern Indiana 0 (28-26,25-16,28-26) | Box score |
| Nov 13, 2010 | Romeoville, IL | Indianapolis 3, Southern Indiana 0 (25-19,25-14,25-18) | Box score |
| Nov 12, 2010 | Romeoville, IL | Southern Indiana 3, Rockhurst 2 (25-20,17-25,16-25,25-14,15-13) | Box score |
| Nov 06, 2010 | Evansville, IN | Southern Indiana 3, Illinois-Springfield 0 (25-12,25-19,25-22) | Box score |
| Nov 05, 2010 | Evansville, IN | Southern Indiana 3, Quincy 0 (25-10,25-20,25-13) | Box score |
| Oct 30, 2010 | St. Louis, Mo. | Southern Indiana 3, Missouri-St. Louis 1 (18-25,29-27,25-20,25-18) | Box score |
| Oct 29, 2010 | Rolla, MO | Southern Indiana 3, Missouri S&T 0 (26-24,25-14,25-21) | Box score |
| Oct 23, 2010 | Evansville, IN | Lewis 3, Southern Indiana 1 (21-25,25-18,25-23,25-13) | Box score |
| Oct 22, 2010 | Evansville, IN | Southern Indiana 3, Wisconsin-Parkside 0 (25-18,25-17,25-19) | Box score |
| Oct 16, 2010 | Aurora, IL | Ashland 3, Southern Indiana 2 (17-25,25-15,26-24,18-25,15-13) | Box score |
| Oct 15, 2010 | Aurora, IL | Southern Indiana 3, Wayne State (MI) 1 (25-11,25-22,20-25,25-21) | Box score |
| Oct 15, 2010 | Aurora, IL | Hillsdale 3, Southern Indiana 0 (25-23,25-16,25-20) | Box score |
| Oct 12, 2010 | Evansville, IN | Southern Indiana 3, Oakland City 0 (25-13,25-13,25-10) | Box score |
| Oct 09, 2010 | Indianapolis, IN | Indianapolis 3, Southern Indiana 0 (25-19,25-20,25-22) | Box score |
| Oct 08, 2010 | Rensselaer, IN | Southern Indiana 3, Saint Joseph's 2 (25-17,16-25,25-16,17-25,15-8) | Box score |
| Oct 3, 2010 | Florence, AL | North Alabama 3, Southern Indiana 0 (25-19,25-22,25-20) | Box score |
| Oct 01, 2010 | Evansville, IN | Southern Indiana 3, Maryville 0 (25-15,25-13,25-18) | Box score |
| Sep 28, 2010 | Evansville, IN | Southern Indiana 3, Kentucky Wesleyan 0 (25-13,25-16,25-7) | Box score |
| Sep 25, 2010 | Springfield, MO | Southern Indiana 3, Drury University 2 (25-23,18-25,25-17,23-25,15-11) | Box score |
| Sep 24, 2010 | Kansas City, MO | Rockhurst 3, Southern Indiana 0 (25-22,25-18,25-23) | Box score |
| Sep 18, 2010 | Evansville, IN | Bellarmine 3, Southern Indiana 2 (17-25,25-21,23-25,25-18,27-25) | Box score |
| Sep 17, 2010 | Evansville, IN | Southern Indiana 3, Northern Kentucky 0 (25-20,28-26,25-20) | Box score |
| Sep 14, 2010 | Evansville, IN | Southern Indiana 3, Kentucky State 0 (25-10,25-14,25-12) | Box score |
| Sep 11, 2010 | St. Louis, MO | Southern Indiana 3, Harding 1 (25-22,25-15,16-25,25-20) | Box score |
| Sep 11, 2010 | St. Louis, MO | Washburn 3, Southern Indiana 0 (25-15,25-13,26-24) | Box score |
| Sep 10, 2010 | St. Louis, MO | Southern Indiana 3, Minnesota-Crookston 2 (25-18,21-25,22-25,25-20,18-16) | Box score |
| Sep 10, 2010 | St. Louis, MO | Truman State 3, Southern Indiana 2 (25-14,25-15,17-25,21-25,15-13) | Box score |
| Sep 04, 2010 | Pensacola, FL | Southern Indiana 3, Alabama-Huntsville 0 (25-22,25-20,25-15) | Box score |
| Sep 03, 2010 | Pensacola, FL | Southern Indiana 3, Wilmington 0 (25-12,25-21,25-11) | Box score |
| Sep 03, 2010 | Pensacola, FL | West Florida 3, Southern Indiana 1 (21-25,25-17,25-14,25-15) | Box score |