| Date | Location | Result | |
| 11/14/21 | Springfield, Mo., UN | Drury 2, Southern Indiana 0 | Box score |
| 11/12/21 | Springfield, Mo., UN | Southern Indiana 1, Mo.-St. Louis 0 (2OT) | Box score |
| 11/07/21 | Indianapolis, UNITED | Southern Indiana 1, Indianapolis 0 | Box score |
| 10/31/21 | St. Charles, Mo. | Southern Indiana 1, Lindenwood 0 | Box score |
| 10/29/21 | St. Louis, usa | Mo.-St. Louis 2, Southern Indiana 1 | Box score |
| 10/24/21 | Evansville, UNITED S | Southern Indiana 3, Missouri S&T 1 | Box score |
| 10/22/21 | Evansville, UNITED S | Southern Indiana 3, Maryville (MO) 2 (OT) | Box score |
| 10/17/21 | Bolivar, UNITED STAT | Southern Indiana 1, Southwest Baptist 0 | Box score |
| 10/15/21 | Springfield, Mo., UN | Southern Indiana 2, Drury 1 | Box score |
| 10/10/21 | Evansville, UNITED S | Southern Indiana 4, William Jewell 0 | Box score |
| 10/08/21 | Evansville, UNITED S | Southern Indiana 1, Rockhurst 0 | Box score |
| 10/03/21 | Quincy, UNITED STATE | Southern Indiana 3, Quincy 2 | Box score |
| 10/01/21 | Kirksville, UNITED S | Truman 2, Southern Indiana 1 (OT) | Box score |
| 09/26/21 | Evansville, UNITED S | Lewis 0, Southern Indiana 0 (2OT) | Box score |
| 09/24/21 | Evansville, UNITED S | Illinois Springfield 2, Southern Indiana 1 | Box score |
| 09/17/21 | Indianapolis, UNITED | Indianapolis 1, Southern Indiana 0 | Box score |
| 09/12/21 | Evansville, UNITED S | McKendree 2, Southern Indiana 1 | Box score |
| 09/08/21 | Cedarville, OH | Southern Indiana 0, Cedarville 0 (2OT) | Box score |
| 09/05/21 | Evansville, UNITED S | Southern Indiana 1, Walsh 0 | Box score |
| 09/02/21 | Evansville, UNITED S | Southern Indiana 2, Trevecca Nazarene 0 | Box score |