| Date | Location | Result | |
| 04/18/21 | East Peoria, IL | Southern Indiana 3, Missouri S&T 2 (24-26,25-21,25-19,22-25,15-9) | Box score |
| 04/17/21 | East Peoria, IL | Southern Indiana 3, Missouri-St. Louis 0 (25-20,25-19,25-21) | Box score |
| 04/16/21 | East Peoria, IL | Southern Indiana 3, Lindenwood 0 (25-20,25-19,26-24) | Box score |
| Apr 10, 2021 | Romeoville, IL | Southern Indiana 3, Lewis 2 (21-25,24-26,25-18,25-21,15-8) | Box score |
| 04/09/21 | Springfield, IL | Southern Indiana 3, Illinois Springfield 1 (25-18,25-18,19-25,25-18) | Box score |
| 04/03/21 | Indianapolis, IN | Southern Indiana 3, Indianapolis 0 (27-25,25-22,25-22) | Box score |
| 03/26/21 | Evansville, IN | Southern Indiana 3, McKendree 1 (26-28,25-21,25-13,25-21) | Box score |
| 03/20/21 | Quincy, IL | Drury 3, Southern Indiana 0 (25-22,25-21,26-24) | Box score |
| 03/20/21 | Quincy, IL | Quincy 3, Southern Indiana 0 (25-22,27-25,25-20) | Box score |
| 03/13/21 | Evansville, IN | Southern Indiana 3, Truman State 1 (25-17,19-25,25-20,25-23) | Box score |
| 03/13/21 | Evansville, IN | Southern Indiana 3, Southwest Baptist 0 (25-11,25-18,25-16) | Box score |
| 03/06/21 | Rolla, MO | Missouri-St. Louis 3, Southern Indiana 0 (25-18,25-17,25-21) | Box score |
| 03/06/21 | Rolla, MO | Southern Indiana 3, Missouri S&T 1 (22-25,25-23,25-21,29-27) | Box score |
| 02/27/21 | St. Louis, MO | Southern Indiana 3, William Jewell 2 (23-25,18-25,25-18,25-23,15-9) | Box score |
| 02/27/21 | St. Louis, MO | Southern Indiana 3, Maryville 1 (21-25,25-14,25-19,25-20) | Box score |
| 02/20/21 | Evansville, IN | Southern Indiana 3, Lindenwood 0 (27-25,25-23,25-14) | Box score |
| 02/20/21 | Evansville, IN | Southern Indiana 3, Rockhurst 0 (25-20,25-16,25-23) | Box score |
| 02/13/21 | Lebanon, IL | Southern Indiana 3, McKendree 0 (27-25,25-22,25-19) | Box score |
| 02/06/21 | Evansville, IN | Southern Indiana 3, Indianapolis 0 (25-14,25-23,25-13) | Box score |
| 01/30/21 | Evansville, IN | Southern Indiana 3, Illinois Springfield 0 (25-22,26-24,25-14) | Box score |
| 01/29/21 | Evansville, IN | Lewis 3, Southern Indiana 2 (22-25,25-22,23-25,25-22,15-6) | Box score |