| Date | Location | Result | |
| 11/20/21 | East Peoria, IL | Missouri-St. Louis 3, Southern Indiana 0 (25-11,25-17,25-15) | Box score |
| 11/19/21 | East Peoria, IL | Southern Indiana 3, Rockhurst 2 (24-26,25-22,25-22,20-25,15-11) | Box score |
| 11/13/21 | Evansville, IN | Lewis 3, Southern Indiana 1 (26-24,25-23,20-25,25-18) | Box score |
| 11/09/21 | Evansville, IN | Southern Indiana 3, Illinois Springfield 0 (25-16,25-22,25-22) | Box score |
| 11/06/21 | Saint Charles, MO | Southern Indiana 3, Lindenwood (MO) 2 (25-23,16-25,25-23,22-25,15-12) | Box score |
| 11/05/21 | Quincy, IL | Quincy 3, Southern Indiana 2 (22-25,25-21,24-26,25-22,15-10) | Box score |
| 11/02/21 | Evansville, IN | Southern Indiana 3, Indianapolis 0 (25-18,25-22,25-13) | Box score |
| 10/30/21 | Evansville, IN | Drury 3, Southern Indiana 1 (23-25,25-23,25-16,25-22) | Box score |
| 10/29/21 | Evansville, IN | Southern Indiana 3, William Jewell 0 (25-18,25-12,25-17) | Box score |
| 10/23/21 | Lebanon, IL | Southern Indiana 3, McKendree 0 (25-19,25-16,25-23) | Box score |
| 10/22/21 | Springfield, IL | Southern Indiana 3, Illinois Springfield 2 (23-25,25-21,25-16,23-25,15-12) | Box score |
| 10/16/21 | Hammond, IN | Grand Valley St. 3, Southern Indiana 1 (25-21,24-26,25-20,25-22) | Box score |
| 10/15/21 | Hammond, IN | Ashland 3, Southern Indiana 1 (25-20,23-25,25-17,26-24) | Box score |
| 10/15/21 | Hammond, IN | Trevecca Nazarene 3, Southern Indiana 0 (25-23,25-15,25-21) | Box score |
| 10/09/21 | Bolivar, MO | Soutwest Baptist 3, Southern Indiana 0 (25-23,25-22,25-17) | Box score |
| 10/08/21 | Kansas City, MO | Rockhurst 3, Southern Indiana 2 (23-25,25-23,25-22,24-26,15-12) | Box score |
| 10/05/21 | Indianapolis, IN | Southern Indiana 3, Indianapolis 2 (17-25,24-26,25-23,25-18,15-13) | Box score |
| 10/02/21 | Evansville, IN | Southern Indiana 3, Missouri-St. Louis 2 (25-20,23-25,23-25,25-21,15-10) | Box score |
| 10/01/21 | Evansville, IN | Southern Indiana 3, Truman State 0 (25-20,25-16,25-20) | Box score |
| 09/28/21 | Evansville, IN | Southern Indiana 3, McKendree 0 (25-17,31-29,25-16) | Box score |
| 09/25/21 | Romeoville, IL | Lewis 3, Southern Indiana 1 (25-11,23-25,25-13,25-15) | Box score |
| 09/18/21 | Rolla, MO | Missouri S&T 3, Southern Indiana 2 (26-24,25-23,19-25,20-25,15-9) | Box score |
| 09/16/21 | Evansville, IN | Southern Indiana 3, Maryville 0 (25-13,25-16,25-22) | Box score |
| 09/11/21 | Evansville, IN | Southern Indiana 3, Wayne St. (MI) 0 (25-12,25-23,25-14) | Box score |
| 09/10/21 | Evansville, IN | Southern Indiana 3, Davis & Elkins 0 (25-19,25-13,25-23) | Box score |
| 09/10/21 | Evansville, IN | Southern Indiana 3, Missouri-St. Louis 1 (25-14,25-12,19-25,25-23) | Box score |
| 09/09/21 | Evansville, IN | Southern Indiana 3, Alabama Huntsville 0 (25-16,25-18,25-13) | Box score |
| 09/04/21 | Pensacola, FL | Southern Indiana 3, Spring Hill 0 (25-19,25-21,25-21) | Box score |
| 09/04/21 | Pensacola, FL | Southern Indiana 3, Palm Beach Atl. 2 (20-25,14-25,25-16,25-22,15-10) | Box score |
| 09/03/21 | Pensacola, FL | West Florida 3, Southern Indiana 0 (25-16,25-14,25-16) | Box score |
| 09/03/21 | Pensacola, FL | Wheeling 3, Southern Indiana 2 (22-25,15-25,27-25,25-22,15-12) | Box score |